USP Reference Standards -I, chemical structure, molecular formula, Reference Standards

USP Ibuprofen RS— Do not dry.Keep container tightly closed.

USP Idarubicin Hydrochloride RS— Do not dry before using.Keep container tightly closed.Store in a freezer.

USP Idoxuridine RS— Do not dry before using.Keep container tightly closed.Protect from light.

USP Ifosfamide RS— Do not dry;determine the water content titrimetrically when used for quantitative analysis.Keep container tightly closed.Store at a temperature not exceeding 25

USP Imidazole RS— Do not dry before using.Keep container tightly closed.Protect from light.

USP Imidurea RS— Dry portion in vacuum over phosphorus pentoxide for 48hours before using.Keep container tightly closed.Store in a desiccator.

USP Iminodibenzyl RS (C14H13N

195.28) —Dry portion over silica gel for 4hours before using.Keep container tightly closed and protected from light.

Change to read:

USP Imipenem Monohydrate RS— Do not dry before using.Keep container tightly closed.

Store in a freezer.

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USP Imipramine Hydrochloride RS— Dry portion at 105

for 2hours before using.Keep container tightly closed.

USP Inamrinone RS— Do not dry before using;determine the water content titrimetrically at the time of use.Keep container tightly closed.

USP Inamrinone Related Compound A RS [5-carboxamide[3,4¢-bipyridin]-6(1H)-one] (C11H9N3O2

215.21) —Do not dry;use as is.Keep container tightly closed and protected from light.

USP Inamrinone Related Compound B RS [N-(1,6-dihydro-6-oxo-(3,4¢-bipyridine)-5-yl)-2-hydroxypropanamide] (C13H13N3O3

259.3) —Do not dry;use as is.

USP Inamrinone Related Compound C RS [1,6-dihydro-6-oxo-(3,4¢-bipyridine)-5-carbonitrile] (C11H7N3O

197.20) —Do not dry;use as is.

USP Indapamide RS— Dry portion at 105

for 4hours before using.Keep container tightly closed.Protect from light.Store in a desiccator.

USP Indigotindisulfonate Sodium RS— Dry portion at 105

for 3hours before using.Keep container tightly closed.Protect from light.This material is hygroscopic.

USP Indocyanine Green RS— Dry portion in vacuum at 50

for 3hours before using.Keep container tightly closed.

USP Indomethacin RS— Dry portion at a pressure below 5mm of mercury at 100

for 2hours before using.Keep container tightly closed.Protect from light.

USP Insulin RS— Preserve at a temperature not exceeding -15

.After opening the vial,without delay,transfer the entire contents of the vial in accurately weighed portions to clean,dry volumetric flasks.Keep the flasks tightly closed,and store in a freezer.Do not dry before use for tests and assays.

USP Insulin (Beef)RS— Do not dry.Store in a freezer at -20

to -18

;after opening,store in a tight container protected from air and humidity.

USP Insulin Human RS— Preserve in a freezer at -20

to -18

,and,after opening the vial,store in a tight container.After opening the vial,without delay,transfer accurately weighed portions to clean,dry volumetric flasks.Keep the flasks tightly closed,and store in a freezer.Do not dry before use for tests and assays.

USP Insulin (Pork)RS— Do not dry.Store in a freezer at -20

to -18

;after opening,store in a tight container protected from air and humidity.

USP Insulin Lispro RS.

USP Iodipamide RS— Dry portion at 105

for 4hours before using.Keep container tightly closed.

USP Iodixanol RS— Dry portion at 105

for 4hours before using.Keep container tightly closed,protected from light,and store in a dry place,preferably in a desiccator.

USP Iodixanol Related Compound A RS [5-amino-N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide].

USP Iodixanol Related Compound C RS [5-[acetyl[3-[[3,5-bis[[(2,3-dihydroxypropyl)amino]carbonyl]-2,4,6-triiodophenyl]amino]-2-hydroxypropyl]amino]N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide].

USP Iodixanol Related Compound D RS [5-[acetyl(2-hydroxy-3-methoxypropyl)amino]-N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide].

USP Iodixanol Related Compound E RS [5-[[3-[[3-[[(2,3-dihydroxypropyl)amino]carbonyl]-5-[[amino]carbonyl]-2,4,6-triiodophenyl](acetylimino)]-2-hydroxypropyl]-(acetylimino)]-N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide].

USPo-Iodohippuric Acid RS (C9H8INO3

305.07) —Do not dry before using.Keep container tightly closed,and store in a desiccator.Protect from light.

USP Iodoquinol RS— Dry portion over silica gel for 4hours before using.Keep container tightly closed.

USP Iohexol RS— Do not dry before using.Keep container tightly closed.Protect from light.

USP Iohexol Related Compound A RS [5-(acetylamino)-N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] —Do not dry.Keep container tightly closed.Protect from light.

USP Iohexol Related Compound B RS [5-amino-N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] —Do not dry.Keep container tightly closed and protected from light.

USP Iohexol Related Compound C RS [N,N¢-bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide] —Do not dry.Keep container tightly closed and protected from light.

USP Iopamidol RS— Dry portion at 105

for 4hours before using.Keep container tightly closed.Protect from light.

USP Iopamidol Related Compound A RS [N,N¢-bis-(1,3-dihydroxy-2-propyl)-5-amino-2,4,6-triiodoisophthalamide] (C14H18I3N3O6

705.03) —Do not dry before using.Keep container tightly closed and protected from light.

USP Iopamidol Related Compound B RS [5-glycolamido-N,N¢-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodoisophthalamide] (C16H20I3N3O7

747.07) —Do not dry.Keep container tightly closed,protected from light,at room temperature.

USP Iopromide RS —Do not dry.For quantitative applications,use a value of 0.979mg iopromide per mg on “as is”basis.Keep container tightly closed.Protect from light.

USP Iopromide Related Compound A RS— Do not dry.Keep container tightly closed and protected from light.

USP Iopromide Related Compound B RS [5-(acetylamino)-N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-N-methyl-1,3-benzenedicarboxamide]—Do not dry.Keep container tightly closed.

USP Iothalamic Acid RS— Dry portion at 105

for 4hours before using.Keep container tightly closed.

USP Ioversol RS.

USP Ioversol Related Compound A RS— Do not dry before using.Keep container tightly closed and protected from light.

USP Ioversol Related Compound B RS— Do not dry before using.Keep container tightly closed and protected from light.

USP Ioxaglic Acid RS.

USP Ioxilan RS— Do not dry.For quantitative applications,determine the water content titrimetrically at the time of use.Keep container tightly closed.Protect from light.

USP Ioxilan Related Compound A RS [5-amino-2,4,6-triiodo-3N-(2-hydroxyethyl)carbamoyl benzoic acid] (C10H9I3N2O4

601.90) —Dry at 105

for 2hours before using.Keep container tightly closed.Protect from light.

USP Ipodate Sodium RS— Dry portion in vacuum at 60

for 3hours before using.Keep container tightly closed.

USP Irbesartan RS— Do not dry.

Add the following:

USP Irbesartan Related Compound A RS [1-pentanoylamino-cyclopentanecarboxylic acid [2'-(1H-tetrazol-5-yl)-byphenyl-4-ylmethyl]-amide] C25H30N6O2

446.54.

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USP Isoetharine Hydrochloride RS— Dry portion at 100

for 4hours before using.

USP Isoflupredone Acetate RS— Dry a portion at 105

for 4hours before using.Keep container tightly closed.Protect from light.

USP Isoflurane RS— Do not dry before using.Keep container tightly closed.Protect from light.

USP Isoflurane Related Compound A RS [1-chloro-2,2,2-trifluoroethylchlorodifluoromethyl ether] (C3HCl2F5O

219.49) .

USP Isoflurane Related Compound B RS [2,2,2-trifluoroethyldifluoromethyl ether] (C3H3F5O

150.05) —Do not dry before using.Keep container tightly closed.Protect from light.[Caution—Extremely volatile liquid.Cool contents before opening ampul. ]

USPL-Isoleucine RS— Dry portion at 105

for 3hours before using.Keep container tightly closed.

USP Isomalathion RS (C10H19O6PS2

330.37) —Do not dry.Keep container tightly closed,and store in a cool place.

USP Isometheptene Mucate RS.

USP Isoniazid RS— Dry portion at 105

for 4hours before using.Keep container tightly closed.Protect from light.

USP Isopropamide Iodide RS— Dry portion in vacuum at 60

for 2hours before using.Keep container tightly closed.Protect from light.

USP Isopropyl Myristate RS— Do not dry before using.After opening ampul,transfer contents to a tightly closed container,and protect from light.

USP Isopropyl Palmitate RS— Do not dry before using.After opening ampul,transfer contents to a tightly closed container.Protect from light.

USP Isoproterenol Hydrochloride RS— Dry portion in vacuum over phosphorus pentoxide for 4hours before using.Keep the container tightly closed and protected from light.

USP Isosorbide RS— For quantitative applications,determine the water content titrimetrically.After opening the ampul,store in a tightly closed container.

USP Diluted Isosorbide Dinitrate RS— [Caution—Undiluted material is explosive by percussion or excessive heat. ]This is a mixture containing 25%of isosorbide dinitrate in mannitol.Do not dry before using.Keep container tightly closed.Prevent exposure to excessive heat.

USP Isotretinoin RS— Do not dry.Store vials at a temperature below 0

;allow to reach room temperature before opening,and use the contents promptly after opening vials.Protect from air and light once vial has been opened.

USP Isoxsuprine Hydrochloride RS— Dry portion at 105

for 1hour before using.Keep container tightly closed.

USP Isradipine RS— Dry portion at 105

for 4hours before using.Keep container tightly closed and protected from light.

USP Isradipine Related Compound A RS [isopropyl methyl 4-(4-benzofurazanyl)-2,6-dimethyl-3,5-pyridinedicarboxylate] (C19H19N3O5

369.38) —Dry portion at 40

in vacuum for 3hours before using.Keep container tightly closed,protected from light,and store in a freezer.

USP Ivermectin RS— Do not dry.Protect from light.Keep container tightly closed.