General Chapters: USP Reference Standards

USP Tacrine Hydrochloride RS— Do not dry. Determine the water content titrimetrically at the time of use. Keep container tightly closed. Store at room temperature. Protect from light.

USP Tamoxifen Citrate RS— Do not dry. Store in a refrigerator. Keep container tightly closed. Protect from light.

USP Taurine RS— Do not dry. Keep container tightly closed. Protect from light.

USP Temazepam RS— Do not dry. Keep container tightly closed.

USP Terazosin Hydrochloride RS— Do not dry. Keep container tightly closed. Protect from light.

USP Terazosin Related Compound A RS [1-(4-amino-6,7-dimethoxy-2-quinazolinyl)piperazine, dihydrochloride] (C14H19N5O2· 2HCl

362.25) —Do not dry. Keep container tightly closed. Protect from light. Store with desiccant in a cold place.

USP Terazosin Related Compound B RS [1-(4-hydroxy-6,7-dimethoxy-2-quinazolinyl))-4-[(tetrahydro-2-furanyl)carbonyl]piperazine] (C19H24N4O5

388.42) —Do not dry. Keep container tightly closed. Protect from light.

USP Terazosin Related Compound C RS [1,4-bis(4-amino-6,7-dimethoxy-2-quinazolinyl)piperazine, dihydrochloride] (C24H28N8O4· 2HCl

565.45) —Do not dry. Keep container tightly closed. Protect from light.

USP Terbutaline Sulfate RS— Dry portion at 105

for 3 hours before using. Keep container tightly closed. Protect from light, and store at controlled room temperature.

USP Terbutaline Related Compound A RS [3,5-dihydroxy-

-t-butylaminoacetophenone sulfate]— Do not dry. Keep container tightly closed.

USP Terconazole RS— Do not dry. Keep container tightly closed.

USP Terpin Hydrate RS— Do not dry; determine the water content titrimetrically at the time of use. Keep container tightly closed.

USP Testolactone RS— Dry portion in vacuum at 100

for 3 hours before using. Keep container tightly closed. Protect from light. Store in a refrigerator.

USP Testosterone RS— Dry portion in vacuum over phosphorus pentoxide for 4 hours before using. Keep container tightly closed.

USP Testosterone Cypionate RS— Do not dry. Keep container tightly closed. Protect from light.

USP Testosterone Enanthate RS— Do not dry before using. Keep container tightly closed. Protect from light. Store in a cold place. Allow to equilibrate to room temperature before opening vial.

USP Testosterone Propionate RS— Dry portion in vacuum over silica gel for 4 hours before using. Keep container tightly closed. Protect from light.

USP Tetracaine Hydrochloride RS— Dry portion in vacuum over phosphorus pentoxide for 18 hours before using. Keep container tightly closed. Protect from light.

USP Tetracycline Hydrochloride RS— Do not dry before using. Keep container tightly closed. Protect from light. Store in a cold place.

USP D8-Tetrahydrocannabinol RS— Store in a refrigerator, protected from light.

USP D9-Tetrahydrocannabinol RS— Store in a refrigerator, protected from light.

USP Tetrahydrozoline Hydrochloride RS— Dry portion at 105

for 2 hours before using. Keep container tightly closed.

USP 3,3¢-5,5¢-Tetraisopropyldiphenol RS.

USP Thalidomide RS— Dry portion in vacuum at 60

for 2 hours before using. Keep container tightly closed. Protect from light.

USP Theophylline RS— This material is the anhydrous form of theophylline. Dry portion at 105

for 4 hours before using. Keep container tightly closed.

USP Thiabendazole RS— Dry portion in vacuum at 100

for 2 hours before using. Keep container tightly closed.

USP Thiacetarsamide RS.

USP Thiamine Hydrochloride RS— Do not dry; determine the water content titrimetrically at the time of use. Keep container tightly closed. Protect from light.

USP Thiethylperazine Maleate RS— Dry portion at 105

for 4 hours before using. Keep container tightly closed and protected from light.

USP Thimerosal RS— Dry portion in vacuum over phosphorus pentoxide to constant weight before using. Keep container tightly closed. Protect from light.

USP Thioguanine RS— Dry in vacuum at 105

for 5 hours before using. Keep container tightly closed.

USP Thiopental RS— Dry portion at 105

for 2 hours before using. Keep container tightly closed.

USP Thioridazine RS— Dry portion in vacuum at 50

for 4 hours before using. Keep container tightly closed. Protect from light.

USP Thioridazine Hydrochloride RS— Dry portion at 105

for 4 hours before using. Keep container tightly closed. Protect from light.

USP Thiostrepton RS— Dry portion in vacuum at a pressure not exceeding 5 mm of mercury at 60

for 3 hours before using. Keep container tightly closed. Protect from light. Store in a cold place.

USP Thiotepa RS— Dry over silica gel for 24 hours before using. Keep container tightly closed. Protect from light. Store in a refrigerator.

USP Thiothixene RS— Do not dry. Keep container tightly closed. Protect from light.

USP (E)-Thiothixene RS— Dry portion in vacuum at 100

for 3 hours before using. Keep container tightly closed and protected from light.

USP L-Threonine RS— Dry portion at 105

for 3 hours before using. Keep container tightly closed.

USP Tiagabine Hydrochloride RS— Do not dry.

USP Tiagabine Related Compound A RS [(R)-ethyl 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylate] (C22H29NO2S2·HCl

440.0) —Do not dry.

USP Racemic Tiagabine Hydrochloride Mixture RS [(S)-(+), (R)-(–)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid, hydrochloride] (C20H25NO2S2·HCl

412.0) —Do not dry.

Add the following:

USP Tiamulin RS.

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USP Tiamulin Fumarate RS— Do not dry. Keep container tightly closed. Protect from light.

USP Tiamulin Related Compound A RS [tosyl pleuromutilin]— Do not dry. Keep container tightly closed. Protect from light.

USP Ticarcillin Monosodium Monohydrate RS (C15H15N2Na O6S2·H2O

424.43) —Do not dry before using. Keep container tightly closed. Protect from light. Store in a cold place.

USP Tiletamine Hydrochloride RS— Dry at 105

for 4 hours before using. Keep container tightly closed.

Change to read:

USP Tilmicosin RS —

Allow vial to reach room temperature before opening. Open and allow to equilibrate for 30 minutes with ambient humidity before weighing for analysis. Determine the water content titrimetrically at the time of use. Keep container tightly closed. Protect from light. Store in a refrigerator.

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USP Timolol Maleate RS— Dry portion in vacuum at 100

to constant weight before using. Keep container tightly closed.

USP Tinidazole RS— Do not dry. Keep container tightly closed. Protect from light. Store in a cool place.

USP Tinidazole Related Compound A RS [(2-methyl-5-nitroimidazole] (C4H5N3O2

127.10) —Do not dry. Keep container tightly closed. Protect from light. Store in a cool place.

USP Tinidazole Related Compound B RS [1-(2-ethyl-sulfonylethyl)-2-methyl-4-nitroimidazole] (C8H13N3O4S

247.28) —Do not dry.

USP Tioconazole RS— Do not dry before using. Keep container tightly closed.

USP Tioconazole Related Compound A RS [1-[2,4-dichloro-

-[(3-thenyl)-oxy]phenethyl]imidazole hydrochloride] (C16H14Cl2 N2OS·HCl

389.73) —Do not dry before using. Keep container tightly closed. Protect from light.

USP Tioconazole Related Compound B RS [1-[2,4-dichloro-

-[(2,5-dichloro-3-thenyl)oxy]phenethyl]imidazole hydrochloride] (C16H12Cl4N2OS·HCl

458.62) —Do not dry before using. Keep container tightly closed. Protect from light.

USP Tioconazole Related Compound C RS [1-[2,4-dichloro-

-[(5-bromo-2-chloro-3-thenyl)-oxy]-phenethyl]imidazole hydrochloride] (C16H13BrCl2N2OS·HCl

468.63) —Do not dry before using. Keep container tightly closed. Protect from light.

Add the following:

USP Tizanidine RS.

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Add the following:

USP Tizanidine Related Compound A RS [4-amino-5-chloro-2,1,3-benzothiadiazole] (C6H4ClN3S

185.63) .

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Add the following:

USP Tizanidine Related Compound B RS [N-acetyltizanidine] (C11H10ClN5OS

295.75) .

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Add the following:

USP Tizanidine Related Compound C RS [1-acetylimidazolidine-2-thione] (C5H8N2OS

144.20) .

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Change to read:

USP Tobramycin RS —

Do not dry. Store in a refrigerator. The material is hygroscopic.

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USP Tocainide Hydrochloride RS— Dry portion at 105

for 2 hours before using. Keep container tightly closed.

USP Alpha Tocopherol RS— Do not dry before using. Keep container tightly closed and protected from light. After opening ampul, without delay withdraw specimen, and store ampul with remaining portion under an inert gas atmosphere in a tightly closed container and protected from light.

USP Alpha Tocopheryl Acetate RS— Do not dry before using. Keep container tightly closed and protected from light. After opening ampul, without delay withdraw specimen, and store ampul with remaining portion under a nitrogen atmosphere.

USP Alpha Tocopheryl Acid Succinate RS— Do not dry. Keep container tightly closed. Protect from light.

USP Tolazamide RS— Dry portion at a pressure not exceeding 5 mm of mercury at 60

for 3 hours before using. Keep container tightly closed.

USP Tolazoline Hydrochloride RS— Dry portion in vacuum over silica gel for 4 hours before using. Keep container tightly closed.

USP Tolbutamide RS— Dry portion at 105

for 3 hours before using. Keep container tightly closed.

USP Tolcapone RS— Do not dry. Keep container tightly closed. Protect from light.

USP Tolcapone Related Compound A RS [4N-methyl-3,4-dihydroxybenzophenone] (C14H12O3

228.24) —Do not dry. Keep container tightly closed. Protect from light.

USP Tolcapone Related Compound B RS [4-hydroxy-3-methoxy-4¢-methyl-5-nitrobenzophenone] (C15H13NO5

287.27) —Do not dry. Keep container tightly closed. Protect from light.

USP Tolmetin Sodium RS— Dry portion in vacuum at 60

for 4 hours before using. Keep container tightly closed.

USP Tolnaftate RS— Dry portion in vacuum at 65

for 3 hours before using. Keep container tightly closed. Store in a refrigerator.

USP o-Toluenesulfonamide RS (C7H9NO2S

171.22) —Do not dry before using. Keep container tightly closed.

USP p-Toluenesulfonamide RS (C7H9NO2S

171.22) —Do not dry before using. Keep container tightly closed.

USP Tomato Extract Containing Lycopene RS .

USP Torsemide RS (Form 1)— Do not dry before using. Keep container tightly closed. Protect from light.

USP Torsemide Related Compound A RS [4-[(3-methylphenyl)amino]-3-pyridinesulfonamide] (C12H13N3O2S

263.32) —Do not dry before using. Keep container tightly closed. Protect from light.

USP Torsemide Related Compound B RS [N-[(n-butylamino)carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide] (C17H22N4O3S

362.45) —Do not dry before using. Keep container tightly closed. Protect from light.

USP Torsemide Related Compound C RS [N-[(ethylamino)carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide] (C15H18N4O3S

334.39) —Do not dry before using. Keep container tightly closed. Protect from light.

USP Tosyl Pleuromutilin RS— (NAME CHANGE) See USP Tiamulin Related Compound A RS.

USP Transplatin RS— Do not dry before using. Keep container tightly closed. Protect from light.

USP Trazodone Hydrochloride RS— Dry portion at a pressure of about 50 mm of mercury at 105

for 3 hours before using. Keep container tightly closed. Protect from light.

Change to read:

USP Trenbolone RS —

Do not dry. Keep container tightly closed. Protect from light. Store in a refrigerator.

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Change to read:

USP Trenbolone Acetate RS —

Do not dry. Keep container tightly closed. Protect from light. Store in a refrigerator.

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USP Tretinoin RS— Do not dry before using. Store in a freezer, protected from light, allow to reach room temperature before opening, and use the contents promptly after opening.

USP Triacetin RS— Do not dry before using. After opening ampul, store in a tightly closed container. Avoid contact with metal.

USP Triamcinolone RS— Dry portion in vacuum at 60

for 4 hours before using. Keep container tightly closed. This material is hygroscopic. Protect accordingly.

USP Triamcinolone Acetonide RS— Do not dry. For quantitative applications, determine the water content titrimetrically. Keep container tightly closed.

USP Triamcinolone Diacetate RS— Dry portion in vacuum at 60

for 4 hours before using. [NOTE—Dried material is hygroscopic.] Keep container tightly closed.

USP Triamcinolone Hexacetonide RS— Dry portion in vacuum at 60

for 4 hours before using. Keep container tightly closed.

USP Triamterene RS— Dry portion in vacuum at 105

for 2 hours before using. Keep container tightly closed. Protect from light.

USP Triazolam RS— Do not dry before using. Keep container tightly closed.

USP Tributyl Citrate RS— Do not dry before using. After opening the ampul, keep the material in a tightly closed container.

USP Trichlormethiazide RS— Dry portion at 105

for 3 hours before using. Keep container tightly closed.

USP Triclosan RS —Do not dry. Keep container tightly closed. Protect from light.

USP Triclosan Related Compound A RS [1,3,7-trichlorodibenzo-p-dioxin] (C12H5Cl3O2)

287.53 .

USP Triclosan Related Compound B RS [2,8 dichlorodibenzo-p-dioxin] (C12H6Cl2O2)

253.09 .

USP Trientine Hydrochloride RS— Dry portion in vacuum at a pressure not exceeding 5 mm of mercury at 40

for 4 hours before using. Keep container tightly closed. Protect from light, and store under an inert gas in a refrigerator.

USP Triethyl Citrate RS— Do not dry before using. After opening the ampul, keep the material in a tightly closed container.

USP Trifluoperazine Hydrochloride RS— Dry portion in vacuum at 60

for 4 hours before using.

USP Triflupromazine Hydrochloride RS— Dry portion at 100

for 2 hours before using. Keep container tightly closed. Protect from light. Store in a cold place.

USP Trifluridine RS— Dry portion in vacuum at 105

for 4 hours before using. Keep container tightly closed and protected from light.

USP Trifluridine Related Compound A RS [5-carboxy-2¢-deoxyuridine] (C10H12N2O7

272.22) —Do not dry before using. Keep container tightly closed and protected from light.

USP Trihexyphenidyl Hydrochloride RS— Dry portion at 105

for 3 hours before using. Keep container tightly closed.

USP Trimeprazine Tartrate RS— Dry portion in vacuum at 60

for 4 hours before using. Keep container tightly closed. Protect from light.

USP Trimethobenzamide Hydrochloride RS— Dry portion at 105

for 4 hours before using. Keep container tightly closed.

USP Trimethoprim RS— Do not dry. Keep container tightly closed. Protect from light.

USP Trioxsalen RS— Do not dry. Keep container tightly closed. Protect from light.

USP Tripelennamine Hydrochloride RS— Dry portion at 105

for 3 hours before using. Keep container tightly closed. Protect from light.

USP Triprolidine Hydrochloride RS— Do not dry; determine the water content titrimetrically at the time of use for quantitative analyses. Keep container tightly closed. Protect from light.

USP Triprolidine Hydrochloride Z-isomer RS— Do not dry. Keep container tightly closed. Protect from light.

USP Trisalicylic Acid RS (C21H14O7

378.34) —Dry portion over silica gel for 4 hours before using. Keep container tightly closed.

USP Troleandomycin RS— Dry portion in vacuum at a pressure not exceeding 5 mm of mercury at 60

for 3 hours before using. Keep container tightly closed, protected from light, and store in a cool place.

USP Tromethamine RS— Dry portion at 105

for 3 hours before using. Keep container tightly closed.

USP Tropicamide RS— Dry portion in vacuum over phosphorus pentoxide at 80

for 4 hours before using. Keep container tightly closed. Protect from light.

USP Trypsin Crystallized RS— Allow container to reach room temperature before opening, and do not dry before using. Determine the loss on drying on a separate portion in vacuum at 60

for 4 hours. Keep container tightly closed, protected from light and heat, and store in a refrigerator.

USP L-Tryptophan RS— Dry portion at 105

for 3 hours before using. Keep container tightly closed.

USP Tubocurarine Chloride RS— Do not dry. Keep container tightly closed. Use as directed on the label.

USP Tylosin RS.

USP Tyloxapol RS— Do not dry before using. Keep container tightly closed.

USP L-Tyrosine RS— Do not dry. Keep container tightly closed.